dna mismatch mechanism
DNA damage is an alteration in the chemical structure of DNA such as a break in a strand of DNA a base missing from the backbone of DNA or a chemically changed base such as 8-OHdG. DNA damage can occur naturally or via environmental factors.
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In this way DNA methylation is a mechanism of cellular memory and it carries important information about the programming of gene expression along with it.
. DNA mismatch repair MMR is a highly conserved DNA repair system Table 122 that greatly contributes to maintain genome stability through the correction of mismatched base pairs and small modifications of DNA bases such as alkylation. The DNA damage response DDR is a complex signal transduction pathway which recognizes when DNA is damaged and initiates. The major source of mismatched base pairs is replication error although it can arise also from other biological processes.
This process is tightly. Patterns of DNA methylation are established early during development with two critical waves of methylation and demethylation occurring during embryogenesis.
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